Thermo Fisher Scientific MUC1 Monoclonal Antibody (S.854.6)

Applications

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with other mucin proteins.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.
MUC1 is highly polymorphic, with each allele encoding a product containing a different number of repeats (30–90), leading to large differences in molecular weight.
It is expressed abundantly in >90% of breast carcinomas and metastases.
Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
The MUC1 gene contains seven exons and produces several alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation are associated with carcinomas.
Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but only some full-length forms have been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.