Thermo Fisher Scientific Phospho-NFkB p105 (Ser933) Monoclonal Antibody (C.478.3)
NFkB p105 (Ser933) 인산화 형태를 특이적으로 인식하는 rabbit monoclonal 항체. Western blot 및 Immunoprecipitation에 적합. Human, Mouse, Rat 등 다양한 종에 반응. Affinity chromatography로 정제된 액상 제품으로, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.478.3 |
| Immunogen | Synthetic phosphopeptide corresponding to amino acids around pSer933 of NFkB p105 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10983140 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NF-kB is a nuclear transcription factor activated by various extra- and intracellular stimuli such as cytokines, UV radiation, stress, injury, and by bacterial and viral products. It regulates cellular events including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family. It is synthesized as a p105 precursor containing an N-terminal conserved RHD region with nuclear localization, DNA-binding, and dimerization domains. NFKB1 (p50) forms homodimers or heterodimers with p65 to form the functional NF-kB factor. NFKB1 (p50) directs nuclear translocation of NF-kB and is crucial for its DNA-binding activity.
Pathological roles of NF-kB have been implicated in AIDS, hematogenic cancer cell metastasis, and rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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