Thermo Fisher Scientific PRDM12 Polyclonal Antibody
PRDM12 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ICC/IF에서 검증됨. 인간 및 마우스 반응성. 합성 펩타이드 면역원 기반. 액상 형태, 1 mg/mL 농도, -20°C 보관. 통증 인지 관련 유전자 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRDM12 (Accession Q9H4Q4), corresponding to amino acid residues L198–C248 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818199 |
Product Specific Information
Antibody detects endogenous levels of total PRDM12.
Target Information
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception.
The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains.
Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP) and hereditary sensory and autonomic neuropathies (HSANs) affecting peripheral sensory and autonomic neurons.
Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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