Thermo Fisher Scientific PIAS1 Polyclonal Antibody
PIAS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적용 가능. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도, PBS와 50% glycerol 저장용액 포함. PIAS1의 SUMO ligase 기능 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PIAS1 (Accession O75925), corresponding to amino acid residues S4–Q54 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818198 |
Product Specific Information
Antibody detects endogenous levels of total PIAS1.
Target Information
PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and its substrate, and acts as a SUMO-tethering factor. It plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT, p53, and steroid hormone signaling pathways. In testis, PIAS1 functions as a nuclear receptor transcriptional coregulator and may contribute to androgen receptor initiation and maintenance of spermatogenesis. Its effects on transcriptional regulation may vary depending on biological context.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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