Thermo Fisher Scientific Phospho-CYLD (Ser422) Polyclonal Antibody
인간, 마우스, 랫트에서 CYLD Ser422 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot에 적합하며, 고순도 정제 및 PBS/glycerol 버퍼에 보존. 종양 억제 단백질 CYLD 연구에 활용 가능.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYLD (Accession Q9NQC7), corresponding to amino acid residues around phosphorylated Ser422 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816561 |
Product Specific Information
This antibody detects endogenous levels of CYLD only when phosphorylated at Ser422.
Target Information
CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, an SH3 binding domain, and a catalytic domain homologous to UCH. CYLD functions as a tumor suppressor affecting the JNK signaling pathway and negatively regulates TRAF2 and NF-κB signaling. It also plays a receptor-dependent role in regulating the I-κB kinase pathway and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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