Thermo Fisher Scientific Phospho-CYLD (Ser422) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of CYLD only when phosphorylated at Ser422.

Target Information

CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, an SH3 binding domain, and a catalytic domain homologous to UCH. CYLD functions as a tumor suppressor affecting the JNK signaling pathway and negatively regulates TRAF2 and NF-κB signaling. It also plays a receptor-dependent role in regulating the I-κB kinase pathway and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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