Thermo Fisher Scientific Phospho-TAB2 (Ser450) Polyclonal Antibody
인간 및 마우스 TAB2 단백질의 Ser450 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot에서 1:500~1:2,000 희석 비율로 사용 가능. 액상 형태로 제공되며, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TAB2 (Accession Q9NYJ8), corresponding to amino acid residues around phosphorylated Ser450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816559 |
Product Specific Information
Antibody detects endogenous levels of TAB2 only when phosphorylated at Ser450.
Target Information
TAB2 is an activator of MAP3K7/TAK1, required for IL-1 induced activation of NF-kappaB and MAPK8/JNK. It forms a kinase complex with TRAF6, MAP3K7, and TAB1, serving as an adaptor linking MAP3K7 and TRAF6. TAB2 also participates in TNFSF11/RANKL-induced signaling through TNFRSF11A/RANK, potentially regulating osteoclast development and function.
TAB2 and TAB3 interact with autophagy mediator Beclin-1; upon autophagy induction, they dissociate from Beclin-1 and bind TAK1. Overexpression inhibits autophagy, while depletion triggers it, suggesting TAB2 and TAB3 act as control points for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-105086_TAB2_Q9NYJ8-1_Rabbit.svg, PA5-105086_TAB2_Q9NYJ8-1_Rabbit_PDP.jpeg)
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