Thermo Fisher Scientific BHC110/LSD1 Polyclonal Antibody

Thermo Fisher Scientific BHC110/LSD1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a marker for epigenetic transcriptional activation, thereby functioning as a corepressor. It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 is part of several histone deacetylase complexes and silences genes via histone demethylation. It oxidizes substrates using FAD to generate imine intermediates that are hydrolyzed. LSD1 demethylates mono- and tri-methylated Lys-4 of histone H3 and may repress neuronal genes. It requires RCOR1/CoREST for nucleosomal activity and may also demethylate Lys-9 of histone H3, affecting androgen receptor target gene expression. Mutations in this gene can cause cleft palate, psychomotor retardation, and distinctive facial features.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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