Thermo Fisher Scientific DMAP1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription.
The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1.
During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication.
The protein also specifically potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription.
DMAP1 is a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6.
It is found in a wide variety of organisms from yeasts to humans. The human DMAP1 gene is localized on chromosome 1p34.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.