Thermo Fisher Scientific alpha-1-Anti-Trypsin Polyclonal Antibody

Thermo Fisher Scientific alpha-1-Anti-Trypsin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.

Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum.
Analysis by SDS-PAGE confirmed the preparation is substantially free of aggregates and shows a banding pattern consistent with purified Rabbit IgG.

Target Information

Alpha-1-AT is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Deficiency is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress of the newborn.
Alpha-1-AT increases as an acute phase response to tissue necrosis and inflammation.
Serum levels are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

• 600-401-147_alpha-1_Antitrypsin_P01009-1_Rabbit.svg
• 600-401-147_alpha-1_Antitrypsin_P01009-1_Rabbit_PDP.jpeg