Thermo Fisher Scientific Collagen Type VI Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at 4°C prior to opening.
• Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use.
• For extended storage, mix with an equal volume of glycerol, aliquot, and freeze at -20°C or below.
• Avoid repeated freeze/thaw cycles.

Typically negligible cross-reactivity against other types of collagens was detected by ELISA against purified standards. Some class-specific anti-collagens may be specific for three-dimensional epitopes, which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin-embedded tissues.
This antibody reacts with most mammalian Type VI collagens and shows negligible cross-reactivity with Type I, II, III, IV, or V collagens. Non-specific cross-reaction with other human serum proteins or non-collagen extracellular matrix proteins is negligible.

Target Information

The COL gene family encodes various collagen chain types, including fibril-forming interstitial collagens (types I, II, III, and V) and basement membrane collagens (type IV), each with multiple isoforms.
Collagens are fibrous extracellular matrix proteins with high tensile strength, forming the major components of connective tissues such as tendons and cartilage.
All collagens contain a triple helix domain and often self-associate laterally to form complex connective structures.
Several collagens also play roles in cell adhesion, maintaining normal tissue architecture and function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.