Thermo Fisher Scientific OLIG1/OLIG2/OLIG3 Monoclonal Antibody (257224)
OLIG1/OLIG2/OLIG3 단백질을 인식하는 Mouse Monoclonal 항체로, 인간 시료에 반응합니다. IHC(F) 및 ICC/IF에 사용 가능하며, 단백질 A/G로 정제된 동결건조 형태입니다. 뇌 및 신경세포 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 8–25 µg/mL |
| Immunocytochemistry (ICC/IF) | 8–25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 257224 |
| Immunogen | E. coli-derived recombinant human Olig1 (aa 1–272) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607923 |
Product Specific Information
- In direct ELISAs, this antibody shows approximately 20% cross-reactivity with recombinant human Olig2 and 50–100% cross-reactivity with recombinant human Olig3.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Olig1 promotes formation and maturation of oligodendrocytes, especially within the brain. It cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate and is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia.
Its chromosomal location on chromosome 21 may play a role in learning deficits associated with Down syndrome.
Tissue specificity: Expressed in the brain, particularly in oligodendrocytes. Strongly expressed in oligodendrogliomas; weak to moderate in astrocytomas; variable in glioblastomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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