Thermo Fisher Scientific OLIG1/OLIG2/OLIG3 Monoclonal Antibody (257224)

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

8-25 µg/mL

-

Immunocytochemistry (ICC/IF)

8-25 µg/mL

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

257224

Immunogen

E. coli-derived recombinant human Olig1 (aa 1-272) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OLIG1/OLIG2/OLIG3,uniProtId:Q8TAK6-1,ncbiNodeId:9606,antigenRange:1-271,antigenLength:271,antigenImageFileName:MA5-23805_OLIG1OLIG2OLIG3_Q8TAK6-1_House_mouse.svg,antigenImageFileNamePDP:MA5-23805_OLIG1OLIG2OLIG3_Q8TAK6-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607923

Product Specific Information

In direct ELISAs, this antibody shows approximately 20% cross-reactivity with recombinant human (rh) Olig2 and 50-100% cross-reactivity with rhOlig3.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Olig1 promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. Olig2 is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.