Thermo Fisher Scientific KCNMA1 Polyclonal Antibody
Thermo Fisher Scientific의 KCNMA1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 토끼 유래 항체입니다. Western blot 및 IHC(P) 분석에 적합하며, E.coli에서 발현된 KCNMA1 단백질을 면역원으로 사용했습니다. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived human KCNMA1 recombinant protein (Position: K124–Q467) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2807013 |
Product Specific Information
- Human KCNMA1 shares 99% amino acid sequence identity with both mouse and rat KCNMA1.
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Potassium channels are ubiquitously expressed proteins serving critical roles in both excitable and non-excitable cells.
The large conductance, calcium-activated potassium channel (Maxi K⁺) is unique in that its activation depends on both intracellular calcium increase and membrane depolarization.
The Maxi K⁺ channel consists of an alpha homotetramer containing voltage-sensing and calcium-binding domains. In vascular smooth muscle, an auxiliary beta-subunit modulates the channel by lowering the calcium concentration required for pore opening by 5–10 fold.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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