Thermo Fisher Scientific CD19 Monoclonal Antibody (HIB19), Super Bright 702, eBioscience
인간 CD19 항원에 특이적인 단클론 항체로 B세포 발달 단계 분석에 적합. Super Bright 702 형광체로 결합되어 405 nm 레이저에서 여기, 702 nm에서 방출. Flow cytometry용으로 최적화되어 있으며 광민감성 주의 필요. 연구용 전용.
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Thermo Fisher Scientific CD19 Monoclonal Antibody (HIB19), Super Bright 702, eBioscience
Applications
- Flow Cytometry (Flow)
Tested dilution: 5 µL (0.25 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Super Bright™ 702, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIB19 |
| Conjugate | Super Bright™ 702 |
| Excitation / Emission Max | 413 / 702 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2688252 |
Available Formats
- Unconjugated
- Alexa Fluor 488, 532, 561, 660, 700
- APC, APC-eFluor 780
- Biotin
- Brilliant UV 395–737
- Brilliant Violet 480–711
- eFluor 450, 506
- FITC
- Functional Grade
- NovaFluor Blue/Red/Violet/Yellow series
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5, PerCP-eFluor 710
- Super Bright 436, 600, 645, 780
- Request custom conjugation
Product Specific Information
The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein expressed by B cells during all stages of development except terminally differentiated plasma cells. Follicular dendritic cells also express CD19. Together with CD21, CD81, Leu13, and MHC class II, CD19 forms a multimolecular complex associated with BCR, inducing tyrosine phosphorylation, calcium flux, and B cell proliferation.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and validated using normal human peripheral blood cells at 5 µL (0.25 µg)/test
- Excitation/Emission: 405 nm / 702 nm (Violet Laser)
- Recommended Filter: 710/50 bandpass
- Light Sensitivity: Protect from light (photo-induced oxidation possible)
- Fixation: Compatible with IC Fixation Buffer (Product #00-8222) or 1-step Fix/Lyse Solution (Product #00-5333) for up to 3 days at 4°C in dark
- Buffer Recommendation: Use Super Bright Complete Staining Buffer (Product #SB-4401) when using multiple Super Bright conjugates
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains, expressed on 100% of peripheral B cells. It is also found on certain myeloid leukemia cells. CD19 acts as a signal-amplifying coreceptor for the B cell receptor (BCR) and regulates normal and malignant B cell proliferation. Mutations cause hypogammaglobulinemia; overexpression leads to B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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