Thermo Fisher Scientific Catenin, beta (p120) Recombinant Mouse Monoclonal Antibody (rCTNNB1, 1507)
Recombinant mouse monoclonal antibody recognizing beta-catenin (p120). Validated for IHC and flow cytometry. High specificity and reproducibility. Suitable for studies on cell adhesion, signaling, and tumor biology.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rCTNNB1, 1507 |
| Immunogen | Recombinant human beta-Catenin (p120) protein fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody tested in direct ELISA.
- For immunohistochemistry (PFA-fixed tissues): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Beta-catenin is an adherens junction (AJ) protein crucial for cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to link adhesion complexes to the actin cytoskeleton.
Beta-catenin also associates with the adenomatous polyposis coli protein and microtubules, participating in multiple signaling pathways (e.g., Wnt/Wingless).
It regulates morphogenesis and is expressed in various hair follicle and epithelial cells. Pathologically, beta-catenin plays a role in pilomatrixoma, medulloblastoma, colorectal and ovarian cancers, and other solid tumors.
In the nucleus, it co-activates Lef/Tcf transcription factors, promoting expression of proliferation-related genes such as cyclin D and c-myc — a mechanism underlying its role in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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