Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI11B2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 binds two related ligands, PDL-1 and PDL-2. Upon binding, PD-1 transduces inhibitory signals that suppress immune activation in the absence of danger signals such as LPS or pathogen-associated molecules.
PD-1 deficiency in mice leads to hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.