Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI8H7), TrueMAB
Human PDCD1 단백질을 인식하는 Mouse IgG2a 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 적합. 고순도 Affinity chromatography 정제, 1 mg/mL 농도. PBS/BSA/glycerol buffer에 보관, 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100–1:900 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8H7 |
| Immunogen | Full length human recombinant PDCD1 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APCs). Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs. PD-1 binds two ligands, PDL-1 and PDL-2, and upon binding, inhibits immune activation in absence of danger signals. PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. PD-1 may migrate at higher molecular weight in SDS-PAGE despite its predicted molecular weight.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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