Thermo Fisher Scientific ROR1 Monoclonal Antibody (OTI3D11), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival.
It is virtually absent from normal pediatric and adult tissues, except for low-level expression in immature B cell precursors (hematogones) and adipocytes.
ROR1 is notably overexpressed and considered a survival factor in several B lymphoid and epithelial malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma.
Identified during PCR-based cloning of a human neuroblastoma cell line, ROR1 and its related receptor ROR2 were categorized as orphan receptors due to their unknown ligands.
Wnt-5a has since been suggested as a ligand, and ROR1 functions as a pseudokinase, promoting proliferation and resistance to apoptosis through interaction with Wnt-5a and TCL1-co-activation of AKT.
ROR1 is expressed as a glycoprotein with extracellular immunoglobulin-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.