Thermo Fisher Scientific PIGR Polyclonal Antibody
Human PIGR 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(Paraffin)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS/40% glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PIGR. Recombinant protein control fragment (Product #RP-88784). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856180 |
Product Specific Information
Immunogen sequence:
LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP EPELVYEDLR GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN PQDKDGSFSV VITGLRKEDA GRYLCGAHS
Target Information
Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.
pIgR associates with secreted dimeric IgA and IgM molecules and undergoes proteolytic cleavage to generate a fragment called secretory component (SC). When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during transcytosis. SC and pIgR are crucial for proper mucosal immunity, acting as molecular chaperones for polymeric Igs to remain intact and enter body fluids.
The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764 amino acid protein containing five units homologous to immunoglobulin variable regions and a transmembrane region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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