Thermo Fisher Scientific KSR1 Polyclonal Antibody
Rabbit polyclonal antibody against human KSR1. Validated for IHC (paraffin) with 1:20–1:50 dilution. Antigen affinity purified and supplied in PBS with 40% glycerol. Suitable for research use in MAPK signaling studies.
- 카탈로그번호
- PA5110765
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to human KSR1 (Product #RP-89822). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.2) with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856176 |
Product Specific Information
Immunogen sequence:
SMIFGVKCKH CRLKCHNKCT KEAPACRISF LPLTRLRRTE SVPSDINNPV DRAAEPHFGT LPKALTKKEH PPAMNHLDSS SNPSSTTSST PSSPAPFPTS SNPSSATTPP NPSPGQRDSR FNFPA
Target Information
KSR1 is part of a multiprotein signaling complex promoting phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, it acts as a MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF. Upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, it dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2. It promotes activation of MAPK1 and/or MAPK3 in response to EGF and cAMP. The physiological relevance of its kinase activity remains uncertain. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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