Thermo Fisher Scientific H3R2me2a Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Dot Blot (DB)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Positive Control: 293T, A431, HeLa, HepG2
• Predicted Reactivity: Mouse (100%), Chimpanzee (100%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3, along with four core histone proteins, binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Post-translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes, including methylation, acetylation, and phosphorylation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.