Thermo Fisher Scientific SHOC2 Polyclonal Antibody
Human 및 Mouse 반응성의 SHOC2 단클론 항체로, Western blot 및 IHC(Paraffin)에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 제품이며, PBS 버퍼와 20% glycerol 포함. RAS-MAPK 신호전달 연구용으로 최적화된 연구용 시약입니다.
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Thermo Fisher Scientific SHOC2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human SHOC2 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.38 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736595 |
Product Specific Information
- Positive Control: A431
- Predicted Reactivity: Rat (100%), Zebrafish (97%), Xenopus laevis (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SHOC2 protein participates in protein binding and transferase activity within the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction.
It is widely expressed and composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmic localization.
SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, forming a highly specific M-Ras effector complex with protein phosphatase 1c (PP1c), essential for MAPK activation by growth factors.
In tumor cells with Ras gene mutations, inhibition of SHOC2 expression suppresses MAPK but not PI3K activity. The SHOC2-PP1c holoenzyme is a potential therapeutic target for MAPK pathway inhibition in cancer.
Aberrant N-myristoylation of SHOC2 has been linked to Noonan-like syndrome with loose anagen hair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-78243_SHOC2_Q9UQ13-1_Rabbit.svg, PA5-78243_SHOC2_Q9UQ13-1_Rabbit_PDP.jpeg)
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