Thermo Fisher Scientific SYNGR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues D(187) P S Q D S S M P Y A P Y V E P(202) of rat Synaptogyrin 1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2200882

Product Specific Information

PA1-1044 detects Synaptogyrin 1 in rat and mouse samples.

PA1-1044 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~25.5 kDa protein representing Synaptogyrin 1 in rat and mouse brain tissue samples.

The PA1-1044 immunogen is a synthetic peptide corresponding to residues D(187) P S Q D S S M P Y A P Y V E P(202) of rat Synaptogyrin 1. This sequence is conserved in mouse and human. The PA1-1044 immunizing peptide (Cat. # PEP-280) is available for use in neutralization and control experiments.

Target Information

Synaptogyrins comprise a family of tyrosine-phosphorylated membrane proteins with two neuronal (SYNGR1 and SYNGR3) and one ubiquitous (SYNGR2) members. SYNGR1 and -3 are synaptic vesicle proteins, residing in some cases on the same synaptic vesicle, and are thought to be involved in the regulation of neurotransmitter release. SYNGR2, by contrast, is absent from synaptic vesicles. The role and localization of a fourth synaptogyrin, SYNGR4, is unclear. The gene for SYNGR1is located at chromosome 22q13, a region linked to schizophrenia; however, there is mixed evidence suggesting that mutations in SYNGR1 might be associated with schizophrenia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.