Thermo Fisher Scientific Androgen Receptor (ARv7 Splice Variant) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

The androgen receptor gene is more than 90 kb long and codes for a protein that has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes.

This gene contains two polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9–34 repeats to the pathogenic 38–62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy’s disease).
Mutations in this gene are also associated with complete androgen insensitivity (CAIS).
Alternative splicing results in multiple transcript variants encoding different isoforms.
[provided by RefSeq, Jan 2017]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.