Thermo Fisher Scientific TMEM173 Monoclonal Antibody (OTI4A7), TrueMAB
인간 TMEM173(STING)에 특이적인 단클론 항체로, NF-κB 및 IRF3 경로 활성화 연구에 활용 가능. ELISA 및 Luminex 분석에 적합하며, 액상 형태로 제공. 고순도 친화 크로마토그래피 정제 제품으로 안정적인 연구용 시약.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:100–1:1,000
Luminex (LUM)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A7 |
| Immunogen | Full length human recombinant protein of human TMEM173 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
STING is a 379-amino-acid signaling protein that acts as an important component of innate immune signaling. It activates NF-kappa-B and IRF3 transcription pathways to induce type I interferon (IFN-alpha and IFN-beta) expression, contributing to antiviral defense.
STING may also function as a translocon and participate in apoptotic signal transduction via association with MHC-II, facilitating detection of intracellular viral RNA and B-form DNA.
It mediates death signaling through activation of the ERK pathway and is generally localized to the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane.
STING is ubiquitously expressed in most tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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