Thermo Fisher Scientific Phospho-Cardiac Troponin I (Ser22, Ser23) Polyclonal Antibody
Cardiac Troponin I의 Ser22/Ser23 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB 및 IHC에 적합. Mouse와 Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Troponin I-C around the phosphorylation site of S22/S23 (aa 22, 23) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609266 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that forms a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit binds to tropomyosin, forming a troponin-tropomyosin complex anchored by TnI binding to actin within muscle thin filaments. When calcium binds to TnC, it induces a structural change that releases the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, useful for differentiating between angina and myocardial infarction. Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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