Thermo Fisher Scientific Phospho-MST1/MST2 (Thr183) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:300

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.

Target Information

STK3 and STK4 are stress-activated, pro-apoptotic kinases that, following caspase-cleavage, enter the nucleus and induce chromatin condensation and DNA fragmentation.
They are key components of the Hippo signaling pathway, regulating organ size and tumor suppression by controlling proliferation and apoptosis.
The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, activate LATS1/2, which then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, affecting gene expression related to proliferation and apoptosis.
STK3/MST2 and STK4/MST1 repress hepatocyte proliferation, prevent activation of adult liver stem cells, and inhibit tumor formation.
They phosphorylate NKX2-1, NEK2, CROCC, and CEP250, playing roles in centrosome disjunction and ESR1 transcriptional activity modulation.
They also regulate RAF1 activation and phosphorylate MOBKL1A, MOBKL1B, and RASSF2 to activate STK38.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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