Thermo Fisher Scientific Phospho-VEGF Receptor 1 (Tyr1333) Polyclonal Antibody
Phospho-VEGF Receptor 1 (Tyr1333) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot, IHC, ELISA에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. 혈관신생 관련 연구용으로 최적화된 제품.
- 카탈로그번호
- PA540252
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-VEGF Receptor 1 (Tyr1333) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:40,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Flt-1 around the phosphorylation site of Y1333 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609309 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase that plays a critical role in angiogenesis. Active angiogenesis is important in various pathological and physiological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
FLT1 may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation, while promoting endothelial cell proliferation and survival in adulthood.
It shows cell-type-specific effects, promoting proliferation in endothelial and some cancer cells but not in normal fibroblasts. FLT1 has high affinity for VEGFA and relatively low kinase activity, possibly functioning as a negative regulator of VEGFA signaling by limiting free VEGFA availability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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