Thermo Fisher Scientific Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11)
Phospho-c-Met (Tyr1234, Tyr1235) 인산화 부위를 인식하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. Human 및 Mouse 반응성, Flow Cytometry에 적합. 일관된 로트 간 품질과 동물 유래 성분 없는 제형으로 연구용에 최적화.
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Applications
- Flow Cytometry (Flow): 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MetY12341235-6F11 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896969 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
MET (cMET) is a receptor-like tyrosine kinase linked to various human malignancies. Upon ligand activation, MET interacts with PI3K subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, activating signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET plays roles in:
- Embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation)
- Adult processes (wound healing, organ regeneration, tissue remodeling)
Dysregulation of MET is associated with cancers including gastric, renal, and breast, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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