Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Monoclonal Antibody (PDCD1, 2720)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs. PD-1 binds two ligands, PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of danger signals such as LPS or pathogen-associated molecules. PD1 knockout mice exhibit hyperactivated immune systems and autoimmune diseases. PD-1 often migrates at a higher molecular weight in SDS-PAGE than predicted.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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