Thermo Fisher Scientific SPHK1 Polyclonal Antibody
SPHK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. 다양한 종(인간, 마우스, 랫, 소)에 반응하며 연구용으로 적합.
- 카탈로그번호
- PA112719
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal of human Sphingosine Kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2195843 |
Product Specific Information
A suggested positive control for this product is MDBK cell lysate.
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P).
S1P signals through G-protein coupled receptors and controls diverse cellular processes.
Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer.
SPHK1 catalyzes the phosphorylation of sphingosine to sphingosine 1 phosphate (S1P), an important signaling molecule with intra- and extracellular functions.
Inside the cell, S1P acts as a signaling molecule like other sphingolipid metabolites such as ceramide and sphingosine.
S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis.
The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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