Thermo Fisher Scientific GPR68 Polyclonal Antibody
Thermo Fisher Scientific의 GPR68 Polyclonal Antibody는 인간 OGR1(GPR68) 단백질을 인식하는 비결합 항체로, WB, IHC, Neutralization 등 다양한 응용에 적합합니다. 고감도 검출 시스템 사용을 권장하며, 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 5–10 µg/mL | |
| Immunohistochemistry (IHC) | Assay-dependent | |
| Neutralization (Neu) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to human OGR1 (GPR68) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS |
| Contains | 0.08% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2279246 |
Product Specific Information
Western blot should be visualized using a high sensitivity secondary/substrate system (e.g., SuperSignal West Femto Maximum Sensitivity Substrate).
A suggested positive control for this product is OGR1 transfected cell lysate.
Target Information
GPR68 (also known as OGR1 - ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It functions as an osteoblastic pH sensor regulating the cell-mediated response to acidosis in bone.
GPR68 mediates its action through G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8.
It also serves as a tumor suppressor in prostate cancer. Mutations in the gene result in amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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