Thermo Fisher Scientific VHL Polyclonal Antibody
Human 및 Mouse 반응성을 가진 VHL 폴리클로날 항체로, WB, IHC, ICC, IP 등 다양한 실험에 적합함. 항원 친화 크로마토그래피로 정제되었으며, 고순도 액상 형태로 제공. VHL 단백질 연구 및 HIF 관련 기전 분석에 활용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:10,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–213 of Human VHL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2544798 |
Product Specific Information
- Recommended positive controls: Myc-DDK-tagged VHL-transfected 293T cells
- Predicted reactivity: Mouse (93%), Rat (91%), Dog (95%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome associated with various malignant and benign tumors. Germline mutations in the VHL gene cause familial inheritance of the syndrome.
The encoded protein forms a complex with elongin B, elongin C, and cullin-2, exhibiting ubiquitin ligase E3 activity. It mediates ubiquitination and degradation of hypoxia-inducible factor (HIF), a transcription factor regulating oxygen-dependent gene expression.
RNA polymerase II subunit POLR2G/RPB7 is also a reported target. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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