Thermo Fisher Scientific ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody (ERb455), CF 488

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:100

Flow Cytometry (Flow)

• Tested Dilution: 5 µL/10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• PE
• Request custom conjugation

Target Information

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55 kD, though multiple isoforms ranging from 36–59 kD have been described. Human ER beta was initially cloned and characterized from testis.
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2).
ER beta binds estrogens with an affinity similar to ER alpha. Some ER beta isoforms dominantly inhibit ER alpha activity in reproductive tissues. ER beta is widely expressed and acts as a tumor suppressor, playing critical roles in prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease, and cardiovascular disease risk.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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