Thermo Fisher Scientific MARVELD2/Tricellulin Polyclonal Antibody
Human MARVELD2(Tricellulin)에 특이적인 Rabbit Polyclonal Antibody로, Western Blot 및 Immunoprecipitation에 적합. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태(1 mg/mL)로 제공. 세포 간 삼중 결합부위 연구에 유용한 연구용 시약.
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Thermo Fisher Scientific MARVELD2/Tricellulin Polyclonal Antibody
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 90 and 140 of human MARVEL domain containing 2 (Tricellulin) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Tight junctions form an important barrier for paracellular transport in epithelial cells. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions, where three adjacent cells meet. It has four membrane-spanning domains similar to claudins and is highly expressed in epithelium-derived tissues such as small intestine, kidney, and lung.
Functional evidence from siRNA studies shows that suppression of tricellulin expression compromises epithelial barrier integrity and tight junction formation. Mutations in the cytosolic domain that disrupt binding to ZO-1 suggest that interactions with other tight junction proteins are critical for tricellulin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: A301-506A-T_MARVELD2_Q8N4S9-1_Rabbit.svg, A301-506A-T_MARVELD2_Q8N4S9-1_Rabbit_PDP.jpeg)
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