Thermo Fisher Scientific SOCS3 Monoclonal Antibody (OTI15F9), TrueMAB
Human SOCS3 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot과 IHC(Paraffin)에 적합. TrueMAB 형식으로 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능하며, 안정적인 액상 형태로 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15F9 |
| Immunogen | Full length human recombinant protein of human SOCS3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.81 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). There are eight members of the SOCS family: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS. Structurally, SOCS proteins have an N-terminal region of variable length, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form part of a classical negative feedback loop regulating cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of SOCS genes occurs rapidly in response to cytokines, and SOCS family members inhibit signaling through various mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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