Thermo Fisher Scientific SOCS3 Monoclonal Antibody (OTI3B8), TrueMAB
Human SOCS3 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, Immunocytochemistry, Flow cytometry에 사용 가능. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B8 |
| Immunogen | Full length human recombinant protein of human SOCS3 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine receptor signaling is negatively regulated by the SOCS (Suppressor of Cytokine Signaling) family, which includes eight members: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS. These proteins share a common structure comprising an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box. SOCS proteins form part of a negative feedback loop that regulates cytokine signal transduction via STAT-induced transcriptional mechanisms. Expression of SOCS genes is rapidly induced by cytokines, and each member modulates signaling through distinct mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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