Thermo Fisher Scientific HDAC4 Monoclonal Antibody (7E2E6)
HDAC4 단백질을 검출하기 위한 Mouse monoclonal 항체로, Western blot, ICC/IF, Flow cytometry, ELISA에 사용 가능. Human 및 Mouse 반응성. Protein G 정제, PBS buffer에 0.05% sodium azide 포함. 단기 4℃, 장기 -20℃ 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E2E6 |
| Immunogen | Purified recombinant fragment of human HDAC4 (aa 456–592) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898450 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal region of core histones (H2A, H2B, H3, and H4).
Histone deacetylation provides an epigenetic repression mark and plays a key role in transcriptional regulation, cell cycle progression, and developmental processes.
HDAC4 functions through large multiprotein complexes and is involved in muscle maturation via interactions with myocyte enhancer factors (MEF2A, MEF2C, MEF2D).
It also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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