Thermo Fisher Scientific Leptin receptor (Isoform B) Polyclonal Antibody
Leptin receptor (Isoform B) 인식용 Rabbit Polyclonal Antibody로, Human, Mouse, Pig, Rat에 반응합니다. WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 사용 가능하며 Protein A로 정제된 액상 형태입니다. 에너지 항상성 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Leptin receptor (Isoform B), amino acids 901–1000 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The leptin (OB-R) receptor is a member of the cytokine receptor superfamily involved in mammalian body weight homeostasis and energy balance. Activation of OB-R by leptin triggers downstream signaling via the JAK/STAT pathway. Leptin can homo-dimerize OB-R extracellular domains, initiating intracellular domain dimerization and signal transduction. Multiple isoforms with differing signaling capacities exist. OB-R long-form transcripts are found in the choroid plexus and hypothalamus, key regions for satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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