Thermo Fisher Scientific Leptin receptor (Isoform B) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily involved in mammalian body weight homeostasis and energy balance. Activation of OB-R by leptin triggers downstream signaling via the JAK/STAT pathway. Leptin can homo-dimerize OB-R extracellular domains, initiating intracellular domain dimerization and signal transduction. Multiple isoforms with differing signaling capacities exist. OB-R long-form transcripts are found in the choroid plexus and hypothalamus, key regions for satiety and energy regulation. Mutations in OB-R (db) or leptin (ob) genes cause early-onset obesity and metabolic abnormalities such as hyperinsulinemia, insulin resistance, and increased adipose tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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