Thermo Fisher Scientific CSK Monoclonal Antibody (5F3)
CSK 단백질을 인식하는 Mouse IgG1 단클론 항체로, WB, ICC/IF, Flow Cytometry, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 원숭이, 랫드 반응성. 비결합형 액상 형태로 제공되며, 4°C 또는 -20°C 보관 권장.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5F3 |
| Immunogen | Purified recombinant fragment of human CSK expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981163 |
Product Specific Information
MA5-15707 targets CSK in indirect ELISA, FACS, IF, and WB applications and shows reactivity with Human, Mouse, Non-human primate, and Rat samples.
The MA5-15707 immunogen is a purified recombinant fragment of human CSK expressed in E. coli.
MA5-15707 detects CSK, which has a predicted molecular weight of approximately 50 kDa.
Target Information
CSK is a tyrosine kinase that downregulates SRC oncoprotein activity through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by mechanisms interfering with this phosphorylation, the CSK gene may function as an antioncogene.
CSK plays an important role in regulating cell growth, differentiation, migration, and immune responses. It phosphorylates tyrosine residues in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1.
CSK is ubiquitously expressed as a ~50 kDa cytosolic protein, with a fraction localized to lipid rafts through interaction with PAG (Csk-binding protein).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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