Thermo Fisher Scientific PERK Monoclonal Antibody (5G5)
EIF2AK3(PERK)을 인식하는 Mouse monoclonal antibody로, WB 및 ELISA에 적합합니다. Human 시료에서 반응하며, 미정제 ascites 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5G5 |
| Immunogen | Purified recombinant fragment of human EIF2AK3 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10986057 |
Product Specific Information
MA5-15705 targets EIF2AK3 in indirect ELISA and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of human EIF2AK3 expressed in E. coli.
MA5-15705 detects EIF2AK3, which has a predicted molecular weight of approximately 125 kDa.
Target Information
EIF2AK3 (PERK) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein synthesis.
In the case of EIF2AK3, signaling is initiated by misfolded proteins in the endoplasmic reticulum.
Defects in EIF2AK3 cause Wolcott-Rallison syndrome (WRS), a rare autosomal recessive disorder characterized by early-onset insulin-dependent diabetes, epiphyseal dysplasia, osteoporosis, growth retardation, and multisystem abnormalities including hepatic and renal dysfunctions, mental retardation, and cardiovascular defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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