Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (rESR1/7162)
인간 Estrogen Receptor alpha를 인식하는 단클론 항체로, 면역조직화학(IHC) 분석에 적합합니다. 고순도 Protein A/G 정제, 액상 형태로 제공되며 PBS 버퍼에 보존제 없이 저장됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (PFA fixed): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rESR1/7162 |
| Immunogen | Recombinant fragment corresponding to C-terminus of human ER-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. ER can regulate gene transcription through recruitment of coactivator or corepressor proteins.
There are two forms of estrogen receptor: alpha (ESR1) and beta (ESR2), encoded by separate genes. Multiple ER-alpha isoforms exist due to alternative RNA splicing (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are essential for sexual development and reproductive function and are also expressed in tissues such as bone. They play roles in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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