Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (ESR1/4008)
인체 유래 Estrogen Receptor alpha(ESR1)를 표적하는 단클론 항체로, IHC 및 Peptide Array 등 다양한 분석에 적합. 재조합 단백질 항원 기반으로 높은 특이성과 재현성을 제공. 단백질 A/G로 정제된 액상 형태, 4°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESR1/4008 |
| Immunogen | Recombinant human ESR1 protein fragment (around aa129–312) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA.
When bound to EREs, ER can regulate gene transcription positively or negatively through recruitment of coactivator or corepressor proteins. Two forms exist—alpha and beta—encoded by ESR1 and ESR2 genes, respectively. Alternative RNA splicing produces at least four known estrogen receptor-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa).
Estrogen receptors are widely expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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