Thermo Fisher Scientific Human TIM-1 Synthetic Peptide
Human TIM-1 중심부의 16개 아미노산 서열로 구성된 합성 펩타이드. PA5-20245 항체의 차단용 블로킹 펩타이드로 사용 가능. 인간 CD365(TIM-1) 연구용으로 적합하며, -20°C에서 보관. 연구용 시약으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the center of human TIM-1.
PEP-0364 can be used as a blocking peptide with polyclonal antibody PA5-20245.
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
Its endogenous ligand is Tim-4. CD365 functions as a receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses, binding via phosphatidylserine on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are linked to infection susceptibility and disease severity. CD365 also plays a role in T cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines.
A soluble form of CD365 can be generated by metalloproteinase-mediated cleavage of the surface protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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