Thermo Fisher Scientific Human TIMD4 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the center of human TIM-4.
PEP-0366 can be used as a blocking peptide with polyclonal antibody PA5-20246.

Target Information

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in regulating T helper (Th)1 and Th2 cell-mediated immunity.
TIM-4, preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, leading to T-cell expansion and cytokine production.
Unlike other TIM family members, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with asthma predisposition in both mice and humans and, due to its connection to TIM-1-triggered Th2 responsiveness, may be considered a candidate gene for asthma susceptibility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.