Thermo Fisher Scientific Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Monoclonal Antibody (SOD1/3923)
인간 SOD1 단백질을 인식하는 단클론 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. Cu-Zn 슈퍼옥사이드 디스뮤타아제 연구에 활용되며, ALS 등 신경질환 관련 연구에 유용합니다. 단백질 A/G 정제, PBS 버퍼 보존, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SOD1/3923 |
| Immunogen | Recombinant full-length human SOD1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: HeLa or Jurkat cells; human breast or ovarian carcinoma.
- Cellular Localization: Cytoplasm.
Specificity Comments:
Cu-Zn superoxide dismutase-1 (SOD1) is a cytosolic enzyme that scavenges oxygen free radicals and requires copper and zinc binding for activity. It catalyzes the dismutation of oxygen radicals to hydrogen peroxide and also exhibits peroxidase and hydroxyl radical–generating activities. SOD1 functions as a homodimer and is ubiquitously expressed in somatic cells.
Defects in the SOD1 gene are linked to neurological diseases such as amyotrophic lateral sclerosis (ALS), Down syndrome, and Alzheimer’s disease. In familial ALS, mutations in SOD1 can lead to loss of zinc binding, reduced scavenging activity, and increased neurotoxicity and motor neuron death.
Target Information
SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes that eliminate free superoxide radicals in the body. This soluble cytoplasmic protein acts as a homodimer to convert harmful superoxide radicals into molecular oxygen and hydrogen peroxide. The other isozyme is mitochondrial.
Mutations in the SOD1 gene are associated with familial amyotrophic lateral sclerosis (ALS). Rare transcript variants have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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