Thermo Fisher Scientific UGT1A6 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total UGT1A6.

Target Information

UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules—such as steroids, bilirubin, hormones, and drugs—into water-soluble, excretable metabolites.
This gene belongs to a complex locus that encodes several UDP-glucuronosyltransferases, containing thirteen unique alternate first exons followed by four common exons. Four of these alternate first exons are pseudogenes, while the remaining nine can be spliced to the common exons, producing proteins with different N-termini but identical C-termini.
Each first exon encodes the substrate binding site and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5′ end of this gene results in two transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.