Thermo Fisher Scientific CK2 alpha-2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CK2 alpha-2. Validated for ICC/IF. Purified by antigen affinity chromatography and supplied in PBS with 40% glycerol. Suitable for detecting CK2-related signaling proteins in research applications.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CK2 alpha. Recombinant protein control fragment (Product #RP-108122) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662643 |
Product Specific Information
- Immunogen sequence: EAMEHPYFYPV VKEQSQPCAD NAVLSSGLTA AR
- Highest antigen sequence identity: Mouse 94%, Rat 94%
Target Information
Casein kinase II (CK2) is a serine/threonine protein kinase found in all eukaryotic cells, indicating essential cellular functions. The holoenzyme is a tetramer composed of two catalytic (alpha or alpha′) and two regulatory (beta) subunits. While the alpha and alpha′ subunits are catalytically identical, regulatory proteins such as cdc2 and Hsp90 preferentially bind to the alpha subunit. CK2 phosphorylates key intracellular signaling proteins involved in tumor suppression (p53, PTEN) and tumorigenesis (myc, jun, NF-kappaB). It also influences Wnt signaling via beta-catenin phosphorylation and the PI3K/Akt signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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