Thermo Fisher Scientific Human APBA1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to a 19 amino acid sequence near the amino terminus of human APBA1.
PEP-1460 can be used as a blocking peptide with polyclonal antibody PA5-34418.

Target Information

The munc-18 interacting protein (Mint) family consists of evolutionarily conserved adaptor proteins involved in membrane transport and organization. In mammals, three isoforms exist: Mint1, Mint2, and Mint3.
While the amino-terminal region shows little sequence conservation, the carboxy-terminal region is highly conserved, containing phosphotyrosine-binding (PTB) and PSD-95/DLG-A/ZO-1 (PDZ) domains that mediate protein interactions.

Mint1 and Mint2 are primarily expressed in the brain and interact with Munc18, a key component of the synaptic vesicle fusion machinery. Mint3, however, is ubiquitously expressed at low levels in the brain and testis and does not interact with Munc18.
Mint3 interacts with the Alzheimer’s disease-related amyloid precursor protein (APP) via its PTB and PDZ domains, potentially linking APP to transport machinery components and regulating its transport, endocytosis, and metabolism.
Abnormal APP metabolism has been implicated in early-onset Alzheimer’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.