Thermo Fisher Scientific Human Caveolin 1 (aa 1-17) Synthetic Peptide

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

-

Product Specifications

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

PEP-146 is a 18 amino acid synthetic peptide whose sequence is from human caveolin-1. The sequence of this peptide is (amino to carboxy terminus): M (1)-S-G-G-K-Y-V-D-S-E-G-H-L-Y-T-V-P-C (18)

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human caveolin-1, catalog # PA1-064 and PA1.1-064. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

Reconstitute with 0.1 mL of distilled water.

Target Information

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.