Thermo Fisher Scientific CD59 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze–thaw cycles.

Target Information

CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC).
It is a key regulator that protects autologous cells from the terminal effector mechanism of the complement cascade.
CD59 associates with the C5b-8 complex and prevents formation of the cytolytic pore within the plasma membrane.
It also acts as a low-affinity ligand of human CD2, contributing to T cell co-stimulation and lymphocyte signal transduction.
Mutations in CD59 cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants of CD59 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.